Dermal Fillers Manufacturer

How To Create Your Own Dermal Filler Product Line

Dr. Korman Laboratories focuses on dermal fillers private label production of dermal fillers and volumizing fillers (in accordance with Customer's requirements).

The Cross Linked Hyaluronic Acid Dermal Filler is a sterile injectable pyrogen-free gel, which is composed of cross-linked hyaluronic acid from a non-animal origin dissolved in a phosphate buffer saline solution. The gel is latex free, viscoelastic, clear, colorless and biodegradable. Synthetically cross-linking the HA improves stability, longevity, and elastoviscous properties. The cross linker we use is 1,4-butanediol diglycidyl ether (BDDE), which forms irreversible carbon bridges between the hyaluronic acid molecules, causing an increase in the in vivo duration of the product.  Crosslinking transforms the linear chains of hyaluronic acid into a three-dimensional structure that is more resistant to enzymatic degradation, while maintaining its biocompatibility.

Another factor that influences the consistency of the final products is the concentration of HA in the gel. Measured in mg/mL, the concentration of HA comprises both soluble molecules (free particles of HA) and insoluble particles (cross-linked). Gels with a higher rigidity have a better ability to withstand the dynamic forces that occur during movements of facial muscles; thus being more suitable for filling deeper and sharper grooves, such as nasolabial and nasogenian folds.

The crosslink density directly affects this ability to absorb water. With a greater amount of crosslinks, the chains of HA will be closer and less flexible, making the connection with water more difficult.

The dermal fillers' concentration vary in the range of 8 mg/ml to 26 mg/ml.

The dermal fillers are available in 1.0 ml single-use pre-filled syringes and are recommended to be used with 271/2" G needles.

CONTACT US

Yosef Levi 23 Str.,
Kiryat Bialik, 2751123 Israel

Tel.: +972-(0) 46893930
Tel.: +972-(0) 46893931

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